Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.

@article{Tronson2010MetabotropicGR,
  title={Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.},
  author={Natalie C Tronson and Yomayra F. Guzm{\'a}n and Anita L. Guedea and Kyu Hwan Huh and Can Gao and Martin Karl Schwarz and Jelena Radulovic},
  journal={Biological psychiatry},
  year={2010},
  volume={68 11},
  pages={1007-15}
}
BACKGROUND Glutamatergic transmission is one of the main components of the stress response; nevertheless, its role in the emotional stress sequelae is not known. Here, we investigated whether interactions between group I metabotropic glutamate receptors (metabotropic glutamate receptor 1 and metabotropic glutamate receptor 5 [mGluR5]) and Homer proteins mediate the delayed and persistent enhancement of fear induced by acute stress. METHODS Antagonists and inverse agonists of metabotropic… CONTINUE READING