Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line.

@article{Yoo2004MetabotropicGR,
  title={Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line.},
  author={Byong Chul Yoo and Eunkyung Jeon and Sung-Hye Hong and Y Shin and Hee Jin Chang and J L Park},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 12 Pt 1},
  pages={
          4176-84
        }
}
PURPOSE 5-Fluorouracil (5-FU) has been the mainstay treatment for colorectal cancer for the past few decades. However, as with other cancers, development of 5-FU resistance has been a major obstacle in colorectal cancer chemotherapy. The purpose of this study was to gain further understanding of the mechanisms underlying 5-FU resistance in colorectal cancer cells. EXPERIMENTAL DESIGN A 5-FU-resistant cell line was established from the human colon cancer cell line SNU-769A. Protein extracts… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Glutamate and its receptors in cancer

Journal of Neural Transmission • 2014
View 4 Excerpts
Highly Influenced

Expression of glutamate receptor subunits in human cancers

Histochemistry and Cell Biology • 2009
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Establishment and characterization of 12 human colorectal-carcinoma cell lines.

International journal of cancer • 1999
View 8 Excerpts
Highly Influenced

GLOBOCAN 2000-cancer incidence, mortality and prevalence worldwide, Version 1.0

J Ferlay, F Bray, P Pisani, DN. Parkin
IARC Cancer Base No • 2001
View 1 Excerpt

Glutamate antagonists limit tumor growth.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 1 Excerpt

Glutamate antagonists: deadly liaisons with cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2001

Glutamate signalling in non-neuronal tissues.

Trends in pharmacological sciences • 2001
View 1 Excerpt

Similar Papers

Loading similar papers…