Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.

@article{Ghose2008MetabotropicGR,
  title={Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.},
  author={Subroto Ghose and Jeremy M Crook and Cynthia L Bartus and Thomas Sherman and Mary M. Herman and Thomas Michael Hyde and Joel Edward Kleinman and Mayada Akil},
  journal={The International journal of neuroscience},
  year={2008},
  volume={118 11},
  pages={1609-27}
}
Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in schizophrenia. We characterized mGluR2 and 3 mRNA in the human prefrontal cortex (PFC) and mesencephalon, and then compared cases with schizophrenia to matched controls. In the human brain, both receptors were expressed in the PFC and, unlike the rodent, in dopaminergic (DA) cell groups. In schizophrenia, we found significantly higher levels of mGluR2 mRNA in the PFC white matter. The expression of mGluR2, 3 in DA… CONTINUE READING
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