Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.

@article{Namkoong2007MetabotropicGR,
  title={Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma.},
  author={Jin Namkoong and Seung S. Shin and Hwa Jin Lee and Yar{\'i} E. Mar{\'i}n and Brian Wall and James S Goydos and Suzie Chen},
  journal={Cancer research},
  year={2007},
  volume={67 5},
  pages={
          2298-305
        }
}
Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies, we reported on a transgenic mouse model that develops melanoma spontaneously. Subsequent studies in these mice identified that the aberrant expression of metabotropic glutamate receptor 1 (GRM1) in melanocytes played a critical role in the onset of melanoma. Confirmation of the etiologic role of GRM1 in melanoma development was shown in a second transgenic line with… 

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