Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices.

@article{Boss1992MetabotropicEA,
  title={Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices.},
  author={Valerie Boss and P Jeffrey Conn},
  journal={Journal of neurochemistry},
  year={1992},
  volume={59 6},
  pages={2340-3}
}
Metabotropic excitatory amino acid (EAA) receptors are coupled to effector systems through G proteins. Because various G protein-coupled receptors stimulate the hydrolysis of phosphatidylcholine by phospholipase D (PLD), we examined the possibility that metabotropic EAA receptors exist that are coupled to the activation of PLD. We found that the selective metabotropic glutamate receptor (mGluR) agonists 1S,3R-amino-1,3-cyclopentanedicarboxylic acid (ACPD) and 1S,3S-ACPD, but not the inactive… CONTINUE READING

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