Metabotropic and ionotropic glutamate receptors regulate calcium channel currents in salamander retinal ganglion cells.

@article{Shen1998MetabotropicAI,
  title={Metabotropic and ionotropic glutamate receptors regulate calcium channel currents in salamander retinal ganglion cells.},
  author={Wen Hong Shen and Malcolm M Slaughter},
  journal={The Journal of physiology},
  year={1998},
  volume={510 ( Pt 3)},
  pages={
          815-28
        }
}
1. Glutamate suppressed high-voltage-activated barium currents (IBa, HVA) in tiger salamander retinal ganglion cells. Both ionotropic (iGluR) and metabotropic (mGluR) receptors contributed to this calcium channel inhibition. 2. Trans-ACPD (1-aminocyclopentane-trans-1S,3R-dicarboxylic acid), a broad-spectrum metabotropic glutamate receptor agonist, suppressed a dihydropyridine-sensitive barium current. Kainate, an ionotropic glutamate receptor agonist, reduced an omega-conotoxin GVIA-sensitive… CONTINUE READING
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