Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives

  title={Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives},
  author={Francesco Ferraguti and Luca Crepaldi and Ferdinando Nicoletti},
  journal={Pharmacological Reviews},
  pages={536 - 581}
Almost 25 years after the first report that glutamate can activate receptors coupled to heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic glutamate receptors. Now, eight members of this family of glutamate receptors, encoded by eight different genes that share distinctive structural features have been identified. The first cloned receptor, the metabotropic glutamate (mGlu) receptor mGlu1 has probably been the most extensively studied mGlu receptor, and in… 

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