Metabonomics: a platform for studying drug toxicity and gene function

@article{Nicholson2002MetabonomicsAP,
  title={Metabonomics: a platform for studying drug toxicity and gene function},
  author={J. Nicholson and J. Connelly and J. Lindon and E. Holmes},
  journal={Nature Reviews Drug Discovery},
  year={2002},
  volume={1},
  pages={153-161}
}
  • J. Nicholson, J. Connelly, +1 author E. Holmes
  • Published 2002
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery programme. Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability. Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug… CONTINUE READING
    1,632 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Biomarker discovery for drug development and translational medicine using metabonomics.
    • H. Keun
    • Medicine
    • Ernst Schering Foundation symposium proceedings
    • 2007
    • 8
    Metabonomics in preclinical drug development
    • 33
    The potential of metabonomics in drug safety and toxicology.
    • J. Griffin
    • Biology, Medicine
    • Drug discovery today. Technologies
    • 2004
    • 34
    Metabonomics and drug development.
    • 3
    Metabonomics and its role in drug development and disease diagnosis
    • 161
    The Opportunities of Metabolomics in Drug Safety Evaluation
    • 3
    Transcriptome and proteome analyses of drug interactions with natural products.
    • 16
    • PDF
    The Current State of Drug Discovery and a Potential Role for NMR Metabolomics
    • R. Powers
    • Chemistry, Medicine
    • Journal of medicinal chemistry
    • 2014
    • 35
    • PDF
    What is the relevance of bioinformatics to pharmacology?
    • 40

    References

    SHOWING 1-10 OF 120 REFERENCES
    Key challenges for toxicologists in the 21st century.
    • L. L. Smith
    • Medicine
    • Trends in pharmacological sciences
    • 2001
    • 73