Metabonomics: a platform for studying drug toxicity and gene function

  title={Metabonomics: a platform for studying drug toxicity and gene function},
  author={J. Nicholson and J. Connelly and J. Lindon and E. Holmes},
  journal={Nature Reviews Drug Discovery},
  • J. Nicholson, J. Connelly, +1 author E. Holmes
  • Published 2002
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery programme. Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability. Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug… CONTINUE READING
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