Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model.

@article{Hu2012MetabonomicPO,
  title={Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model.},
  author={Ze-Ping Hu and Edward R. Browne and Tao Liu and Thomas E. Angel and Paul Chi-Lui Ho and Eric Chun Yong Chan},
  journal={Journal of proteome research},
  year={2012},
  volume={11 12},
  pages={
          5903-13
        }
}
Identification of molecular mechanisms underlying early stage Alzheimer's disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, nontargeted metabonomics of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild-type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild-type mice (Q2Y=0… CONTINUE READING

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