Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium.

@article{Yan2009MetabonomicCO,
  title={Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium.},
  author={Shikai Yan and Bin Wu and Zhongying Lin and Huizi Jin and Jianhua Huang and Yun Yang and Xinmin Zhang and Ziyin Shen and W. L. Zhang},
  journal={Molecular bioSystems},
  year={2009},
  volume={5 10},
  pages={1204-13}
}
A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18 and 24 month-old rats and TFE-administered rats have been profiled by LC/MS. Thirty age-related endogenous metabolites were discovered by partial least squares (PLS) and Hotelling's T(2) control… CONTINUE READING