Metabolomics study of stepwise hepatocarcinogenesis from the model rats to patients: potential biomarkers effective for small hepatocellular carcinoma diagnosis.

@article{Tan2012MetabolomicsSO,
  title={Metabolomics study of stepwise hepatocarcinogenesis from the model rats to patients: potential biomarkers effective for small hepatocellular carcinoma diagnosis.},
  author={Yexiong Tan and Peiyuan Yin and Liang Tang and Wenbin Xing and Qiang Huang and Dan Cao and XinJie Zhao and Wenzhao Wang and Xin Lu and Zhiliang Xu and Hong-yang Wang and Guowang Xu},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 2},
  pages={M111.010694}
}
The aim of this study is to find the potential biomarkers from the rat hepatocellular carcinoma (HCC) disease model by using a non-target metabolomics method, and test their usefulness in early human HCC diagnosis. The serum metabolic profiling of the diethylnitrosamine-induced rat HCC model, which presents a stepwise histopathological progression that is similar to human HCC, was performed using liquid chromatography-mass spectrometry. Multivariate data analysis methods were utilized to… CONTINUE READING

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