Metabolomics methods for the synthetic biology of secondary metabolism.

  title={Metabolomics methods for the synthetic biology of secondary metabolism.},
  author={Q. Nguyen and Maria Elena Merlo and Marnix H. Medema and Andris Jankevics and Rainer Breitling and Eriko Takano},
  journal={FEBS letters},
  volume={586 15},
Many microbial secondary metabolites are of high biotechnological value for medicine, agriculture, and the food industry. Bacterial genome mining has revealed numerous novel secondary metabolite biosynthetic gene clusters, which encode the potential to synthesize a large diversity of compounds that have never been observed before. The stimulation or "awakening" of this cryptic microbial secondary metabolism has naturally attracted the attention of synthetic microbiologists, who exploit recent… CONTINUE READING


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