Metabolomics method based on ultra high performance liquid chromatography with time-of-flight mass spectrometry to analyze toxins in fresh and dried toad venom.

@article{Ma2016MetabolomicsMB,
  title={Metabolomics method based on ultra high performance liquid chromatography with time-of-flight mass spectrometry to analyze toxins in fresh and dried toad venom.},
  author={Hongyue Ma and Huixia Niu and Qin Cao and Jing Zhou and Yan Gong and Zhenhua Zhu and Xiang Guo Lv and Liu-qing Di and Dawei Qian and Qi-nan Wu and Jinao Duan},
  journal={Journal of separation science},
  year={2016},
  volume={39 24},
  pages={4681-4687}
}
Drying is a critical step to prolong the storage time in natural medicine processing but it changes the chemical characteristics of the product. In this study, research was performed to characterize the metabolomic changes in toad venom induced by vacuum-drying at 60°C and air-drying at room temperature by ultra high performance liquid chromatography coupled with pattern recognition approaches. In total 52 metabolites, down-regulated or up-regulated, were identified as potential chemical… CONTINUE READING

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