Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.

@article{Sadhukhan2016MetabolomicsassistedPI,
  title={Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.},
  author={Sushabhan Sadhukhan and Xiaojing Liu and Dongryeol Ryu and Ornella D Nelson and John A. Stupinski and Zhi Li and Wei Yea Chen and Sheng Zhang and Robert Samuel Weiss and Jason W. Locasale and Johan Auwerx and Hening Lin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 16},
  pages={4320-5}
}
Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is regulated by sirtuin 5 (SIRT5). Although numerous proteins are modified by lysine succinylation, the physiological significance of lysine succinylation and SIRT5 remains elusive. Here, by profiling acyl-CoA molecules in various mouse tissues, we have discovered that different tissues have different acyl-CoA profiles and that… CONTINUE READING

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Although numerous proteins are modified by lysine succinylation , the physiological significance of lysine succinylation and SIRT5 remains elusive .
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