Metabolomics as a tool for target identification in strain improvement: the influence of phenotype definition.

@article{Braaksma2011MetabolomicsAA,
  title={Metabolomics as a tool for target identification in strain improvement: the influence of phenotype definition.},
  author={Machtelt Braaksma and S. Bijlsma and Leon Coulier and Peter J. Punt and Mari{\"e}t J. van der Werf},
  journal={Microbiology},
  year={2011},
  volume={157 Pt 1},
  pages={147-59}
}
For the optimization of microbial production processes, the choice of the quantitative phenotype to be optimized is crucial. For instance, for the optimization of product formation, either product concentration or productivity can be pursued, potentially resulting in different targets for strain improvement. The choice of a quantitative phenotype is highly… CONTINUE READING