Metabolomics approach for multibiomarkers determination to investigate dengue virus infection in human patients.

@article{Shahfiza2017MetabolomicsAF,
  title={Metabolomics approach for multibiomarkers determination to investigate dengue virus infection in human patients.},
  author={Nurul Shahfiza and Hasnah Osman and Tang Thean Hock and Abdel-Hamid Zaki Abdel-Hamid},
  journal={Acta biochimica Polonica},
  year={2017},
  volume={64 2},
  pages={
          215-219
        }
}
BACKGROUND Dengue is one of the major public health problems in the world, affecting more than fifty million cases in tropical and subtropical region every year. The metabolome, as pathophysiological end-points, provide significant understanding of the mechanism and progression of dengue pathogenesis via changes in the metabolite profile of infected patients. Recent developments in diagnostic technologies provide metabolomics for the early detection of infectious diseases. METHODS The mid… 

Figures and Tables from this paper

Metabolomic Insights into Human Arboviral Infections: Dengue, Chikungunya, and Zika Viruses

This review focuses on lessons derived from metabolomics studies on samples from arbovirus-infected humans, and focuses on the interpretation of identified molecular features.

Dengue and metabolomics in humans.

The results gathered here show that metabolomic approaches prove to be an excellent and viable way to expand knowledge about DF, and some results are still conflicting between studies.

H-NMR-based metabolite profiling for biomarker identification.

Metabolomics applied in the study of emerging arboviruses caused by Aedes aegypti mosquitoes: A review

An overview of the basic concepts of metabolomics workflow and advances in this field are presented, and research articles that use this omic approach to study these arboviruses are compiled.

Saliva NMR-Based Metabolomics in the War Against COVID-19

The importance of comprehending the SARS-CoV-2 salivary metabolomic fingerprint is discussed and the situation of Brazil on the frontlines of the war against COVID-19 is highlighted.

Single Cell Metabolomics: A Future Tool to Unmask Cellular Heterogeneity and Virus-Host Interaction in Context of Emerging Viral Diseases

Single cell metabolomics (SCM) emerges as necessity to explore such minute details of virus-host interface and the potential of SCM has already been exploited to resolve several biological conundrums.

Association between urinary per- and poly-fluoroalkyl substances and COVID-19 susceptibility

Virus-host protein-protein interactions as molecular drug targets for arboviral infections

This review focuses on host-virus PPIs of arboviral infections that directly affect the host immune signaling and metabolic pathways that will develop new therapeutic tools to treat viral infections.

References

SHOWING 1-10 OF 22 REFERENCES

Metabolomics for characterization of gender differences in patients infected with dengue virus.

Metabolomics approach for investigation of effects of dengue virus infection using the EA.hy926 cell line.

Application of metabolomics is demonstrated to improve understanding of the effect of dengue infection on endothelial cells' metabolome by combining proton nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) together with pattern recognition tools in a metabolomic study used to investigate the effects of d Dengue virus infection.

Dengue Virus Pathogenesis: an Integrated View

A personalized approach to the study of pathogenesis will elucidate the basis of individual risk for development of DHF and DSS as well as identify the genetic and environmental bases for differences in risk forDevelopment of severe disease.

A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever.

Analysis of the liver profile showed that liver dysfunction was commoner in DHF compared to DF, indicating that the degree of liver impairment may be related to the severity of DHF.

The Human Urine Metabolome

A comprehensive, quantitative, metabolome-wide characterization of human urine and the identification and annotation of several previously unknown urine metabolites and to substantially enhance the level of metabolome coverage are undertaken.

Neurological manifestations of dengue infection

Frontiers in metabolomics for cancer research: Proceedings of a National Cancer Institute workshop

This manuscript is a summary of the workshop that highlighted the existing research and literature in the field of metabolomics for cancer research and research recommendations that may provide important steps forward for the future.

Dengue infections and circulating serotypes in Negeri Sembilan, Malaysia

The aim of this study was to determine the co-circulation of the four different dengue virus serotypes in Negeri Sembilan, Malaysia, with the DEN-2 and DEN-3 serotypes being the most predominant in the first half of the year.

Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models.

The S-plot is proposed as a tool for visualization and interpretation of multivariate classification models, e.g., OPLS discriminate analysis, having two or more classes, and an improved visualization and discrimination of interesting metabolites could be demonstrated.

Diabetes with Hypertension as Risk Factors for Adult Dengue Hemorrhagic Fever in a Predominantly Dengue Serotype 2 Epidemic: A Case Control Study

Adult dengue patients in Singapore who were 30–49 years, Chinese, female, had diabetes or diabetes with hypertension were at greater risk of developing DHF during epidemic of predominantly serotype 2.