Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids

Abstract

All organisms, including humans, possess a huge number of uncharacterized enzymes. Here we describe a general cell-based screen for enzyme substrate discovery by untargeted metabolomics and its application to identify the protein α/β-hydrolase domain-containing 3 (ABHD3) as a lipase that selectively cleaves medium-chain and oxidatively truncated… (More)
DOI: 10.1038/nchembio.659

Topics

2 Figures and Tables

Slides referencing similar topics