Metabolomics and proteomics technologies to explore the herbal preparation affecting metabolic disorders using high resolution mass spectrometry.

@article{Zhang2017MetabolomicsAP,
  title={Metabolomics and proteomics technologies to explore the herbal preparation affecting metabolic disorders using high resolution mass spectrometry.},
  author={Aihua Zhang and Xiaohang Zhou and Hongwei Zhao and Shiyu Zou and Chung Wah Ma and Qi Liu and Hui Sun and Liang Liu and Xijun Wang},
  journal={Molecular bioSystems},
  year={2017},
  volume={13 2},
  pages={320-329}
}
An integrative metabolomics and proteomics approach can provide novel insights in the understanding of biological systems. We have integrated proteome and metabolome data sets for a holistic view of the molecular mechanisms in disease. Using quantitative iTRAQ-LC-MS/MS proteomics coupled with UPLC-Q-TOF-HDMS based metabolomics, we determined the protein and metabolite expression changes in the kidney-yang deficiency syndrome (KYDS) rat model and further investigated the intervention effects of… CONTINUE READING

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