Metabolomics and Metabolic Diseases: Where Do We Stand?

@article{Newgard2017MetabolomicsAM,
  title={Metabolomics and Metabolic Diseases: Where Do We Stand?},
  author={Christopher B. Newgard},
  journal={Cell metabolism},
  year={2017},
  volume={25 1},
  pages={
          43-56
        }
}
Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, has undergone a rapid technological evolution in the past two decades. These advances have led to the application of metabolomics to defining predictive biomarkers for incident cardiometabolic diseases and, increasingly, as a blueprint for understanding those diseases' pathophysiologic mechanisms. Progress in this area and challenges for the future are reviewed here. 

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References

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Showing 1-10 of 132 references

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

C. Jang, S. F. Oh, +7 authors A Ibrahim
Nat. Med • 2016
View 6 Excerpts
Highly Influenced

on lipid droplets and develop hepatic steatosis

P. Spégel, V. V. Sharoyko, +8 authors S.G
Biochem. J. 450, • 2013
View 6 Excerpts
Highly Influenced

phosphatidylcholine promotes cardiovascular disease

T. J. Wang, D. Ngo, +8 authors E.P
J. Clin. Invest • 2013
View 6 Excerpts
Highly Influenced

Metabolite profiles and the risk of developing diabetes

Nature Medicine • 2011
View 16 Excerpts
Highly Influenced

Insulin secretion in obesity.

The New England journal of medicine • 1967
View 11 Excerpts
Highly Influenced

acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell

N. D. Palmer, R. D. Stevens, +5 authors D. W. Bowden
2015
View 5 Excerpts
Highly Influenced

ceptor coactivator-3 resembles the human CACT metabolic myopathy

N. Zamboni, A. Saghatelian, G. J. Patti
Cell Metab • 2015
View 7 Excerpts
Highly Influenced

metabolic signature for the transition from gestational diabetes mellitus to type 2 diabetes. Diabetes

T. C. Alves, R. L. Pongratz, +6 authors R. G. Kibbey
Cell Metab • 2015
View 6 Excerpts
Highly Influenced

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