Metabolomics Analysis of Metabolic Effects of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibition on Human Cancer Cells

@inproceedings{Tolstikov2014MetabolomicsAO,
  title={Metabolomics Analysis of Metabolic Effects of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibition on Human Cancer Cells},
  author={Vladimir Tolstikov and Alexander Nikolayev and Sucai Dong and Genshi Zhao and Ming-shang Kuo},
  booktitle={PloS one},
  year={2014}
}
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensively studied over the past decade due to its role as a key regulator of nicotinamide adenine dinucleotide-consuming enzymes. NAMPT is also known as a potential target for therapeutic intervention due to its involvement in disease. In the current… CONTINUE READING
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Significant changes were observed in the amino acids metabolism and the purine and pyrimidine metabolism .
Significant changes were observed in the amino acids metabolism and the purine and pyrimidine metabolism .
Significant changes were observed in the amino acids metabolism and the purine and pyrimidine metabolism .
Significant changes were observed in the amino acids metabolism and the purine and pyrimidine metabolism .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
We also observed metabolic alterations in glycolysis , the citric acid cycle ( TCA ) , and the pentose phosphate pathway .
This study suggests that global metabolomics can be a useful tool in pharmacological studies of the mechanism of action of drugs at a cellular level .
This study suggests that global metabolomics can be a useful tool in pharmacological studies of the mechanism of action of drugs at a cellular level .
Significant changes were observed in the amino acids metabolism and the purine and pyrimidine metabolism .
Significant changes were observed in the amino acids metabolism and the purine and pyrimidine metabolism .
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