Metabolomic and transcriptomic stress response of Escherichia coli

  title={Metabolomic and transcriptomic stress response of Escherichia coli},
  author={Szymon Jozefczuk and Sebastian Klie and Gareth Catchpole and Jędrzej Szymański and {\'A}lvaro Cuadros-Inostroza and Dirk Steinhauser and Joachim Selbig and Lothar Willmitzer},
  booktitle={Molecular systems biology},
Environmental fluctuations lead to a rapid adjustment of the physiology of Escherichia coli, necessitating changes on every level of the underlying cellular and molecular network. Thus far, the majority of global analyses of E. coli stress responses have been limited to just one level, gene expression. Here, we incorporate the metabolite composition together with gene expression data to provide a more comprehensive insight on system level stress adjustments by describing detailed time-resolved… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS