Metabolomic and Network Analysis of Pharmacotherapies for Sensorineural Hearing Loss

  title={Metabolomic and Network Analysis of Pharmacotherapies for Sensorineural Hearing Loss},
  author={Tjeerd J Muurling and Konstantina M. Stankovic},
  journal={Otology \& Neurotology},
Hypothesis Different pharmacotherapies for sensorineural hearing loss (SNHL) are interconnected in metabolic networks with molecular hubs. Background Sensorineural hearing loss is the most common sensory deficit worldwide. Dozens of drugs have shown efficacy against SNHL in animal studies and a few in human studies. Analyzing metabolic networks that interconnect these drugs will point to and prioritize development of new pharmacotherapies for human SNHL. Methods Drugs that have shown efficacy… 
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A Comprehensive Network and Pathway Analysis of Human Deafness Genes
  • G. Stamatiou, K. Stankovic
  • Medicine, Biology
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • 2013
A number of molecules that are likely to be key mediators of genetic hearing loss were identified through three different network and pathway analyses and included new candidate genes for deafness.
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