Metabolomic analysis of urine samples by UHPLC-QTOF-MS: Impact of normalization strategies.

@article{Gagnebin2017MetabolomicAO,
  title={Metabolomic analysis of urine samples by UHPLC-QTOF-MS: Impact of normalization strategies.},
  author={Yoric Gagnebin and David Tonoli and Pierre Lescuyer and Bel{\'e}n Ponte and Sophie de Seigneux and P Y Martin and Julie Schappler and Julien Boccard and Serge L. Rudaz},
  journal={Analytica chimica acta},
  year={2017},
  volume={955},
  pages={
          27-35
        }
}
Among the various biological matrices used in metabolomics, urine is a biofluid of major interest because of its non-invasive collection and its availability in large quantities. However, significant sources of variability in urine metabolomics based on UHPLC-MS are related to the analytical drift and variation of the sample concentration, thus requiring… CONTINUE READING