Metabolomic analysis of urinary organic acids following intraperitoneal injection with γ-hydroxybutyric acid in rats

Abstract

γ-Hydroxybutyricacid (GHB) has been used as a prescription medicine for the treatment of narcolepsy and alcohol dependence. Quantification of GHB in biological fluids from GHB intoxication cases is not clear for verifying exposure to GHB due to the presence of endogenous GHB, which is rapidly metabolized, via GABA and/or succinic semialdehyde, to succinic… (More)
DOI: 10.1007/s11306-016-1125-3

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