Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry.

@article{Yang2011MetabolomicAO,
  title={Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry.},
  author={Jindan Yang and Xiaowei Sun and Zhijing Feng and Dongfang Hao and Maoqing Wang and Xiujuan Zhao and Changhao Sun},
  journal={Toxicology letters},
  year={2011},
  volume={206 3},
  pages={306-13}
}
The purpose of the current study was to assess the effects of long-term exposure to low levels of DDVP on the biochemical parameters and metabolic profiles of rats. Three different doses (2.4, 7.2, and 21.6 mg/kg body weight/day) of DDVP were administered to rats through their drinking water over 24 weeks. Significant changes in blood cholinesterase… CONTINUE READING