Metabolomic Effects of Hormone Therapy and Associations With Coronary Heart Disease Among Postmenopausal Women

@article{Balasubramanian2020MetabolomicEO,
  title={Metabolomic Effects of Hormone Therapy and Associations With Coronary Heart Disease Among Postmenopausal Women},
  author={Raji Balasubramanian and Olga V Demler and Marta Guasch-Ferr{\'e} and Nina P Paynter and Ryan Sheehan and Simin Liu and JoAnn E. Manson and Jordi Salas-Salvad{\'o} and Miguel Angel Mart{\'i}nez-Gonz{\'a}lez and Frank B. Hu and Clary B. Clish and Kathryn M. Rexrode},
  journal={Circulation: Genomic and Precision Medicine},
  year={2020},
  volume={13},
  pages={e002977}
}
Supplemental Digital Content is available in the text. Background: In the WHI-HT trials (Women’s Health Initiative Hormone Therapy), treatment with oral conjugated equine estrogens and medroxyprogesterone acetate (CEE+MPA) resulted in increased risk of coronary heart disease (CHD), whereas oral conjugated equine estrogens (CEE) did not. Methods: Four hundred eighty-one metabolites were measured at baseline and at 1-year in 503 and 431 participants in the WHI CEE and CEE+MPA trials, respectively… Expand

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