Metabolome and proteome changes with aging in Caenorhabditis elegans

@article{Copes2015MetabolomeAP,
  title={Metabolome and proteome changes with aging in Caenorhabditis elegans},
  author={Neil Copes and Clare B. Edwards and Dale Chaput and M. Saifee and P. Bradshaw},
  journal={Experimental Gerontology},
  year={2015},
  volume={72},
  pages={67-84}
}
To expand the understanding of aging in the model organism Caenorhabditis elegans, global quantification of metabolite and protein levels in young and aged nematodes was performed using mass spectrometry. With age, there was a decreased abundance of proteins functioning in transcription termination, mRNA degradation, mRNA stability, protein synthesis, and proteasomal function. Furthermore, there was altered S-adenosyl methionine metabolism as well as a decreased abundance of the S-adenosyl… Expand
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