Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway

@article{Hamada2009MetabolitesOS,
  title={Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway},
  author={Nanako Hamada and Yasunori Fujita and Arisa Tanaka and Makoto Naoi and Yoshinori Nozawa and Yoshiko Ono and Yoshinori Kitagawa and Namino Tomimori and Yoshinobu Kiso and Masafumi Ito},
  journal={Journal of Neural Transmission},
  year={2009},
  volume={116},
  pages={841-852}
}
Sesamin, a major lignan in sesame seeds, exhibits various health benefits. Here, we investigated effects of sesamin, its stereoisomer episesamin, and their metabolites on neuronal differentiation in rat pheochromocytoma PC12 cells. Among all compounds tested, primary metabolites of sesamin and episesamin, SC-1 and EC-1 {S- and R-epimer of 2-(3,4-methylenedioxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo [3.3.0]octane}, were the most potent to induce neuronal differentiation. SC-1 alone… CONTINUE READING

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