Metabolites of procainamide and practolol inhibit complement components C3 and C4.

@article{Sim1988MetabolitesOP,
  title={Metabolites of procainamide and practolol inhibit complement components C3 and C4.},
  author={Edith Sim and Lorraine Stanley and Eric W. Gill and Alun Jones},
  journal={The Biochemical journal},
  year={1988},
  volume={251 2},
  pages={323-6}
}
Drug-induced systemic lupus erythematosus arises from toxic side-effects of administration of hydralazine, isoniazid, procainamide and practolol. Hydralazine and isoniazid are nucleophilic drugs and inhibit the covalent binding reaction of complement components, C3 and C4, an effect likely to lead to deposition of immune complexes (a feature of systemic lupus erythematosus). Procainamide and practolol do not themselves inhibit C3 and C4. A range of metabolites and putative metabolites of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.

Complement in Health and in Disease.

Canadian Medical Association journal
View 1 Excerpt

Similar Papers

Loading similar papers…