Metabolite profiling of plant extracts by ultra-high-pressure liquid chromatography at elevated temperature coupled to time-of-flight mass spectrometry.

@article{Grata2009MetabolitePO,
  title={Metabolite profiling of plant extracts by ultra-high-pressure liquid chromatography at elevated temperature coupled to time-of-flight mass spectrometry.},
  author={Elia Grata and Davy Guillarme and Ga{\'e}tan Glauser and Julien Boccard and Pierre-Alain Carrupt and J. -L. Veuthey and Serge Rudaz and Jean-Luc Wolfender},
  journal={Journal of chromatography. A},
  year={2009},
  volume={1216 30},
  pages={
          5660-8
        }
}
Detailed metabolite profiling of crude plant extracts, mandatory for both quality control and metabolomics purposes, requires high-resolution separation and sensitive detection with a reasonable sample throughput. In this respect, the use of ultra-high-pressure liquid chromatography (UHPLC) working at high temperature (HT) and coupled to time-of-flight mass spectrometry (TOF-MS) was evaluated in the present study in terms of achievable peak capacities for given analysis times. Prior to the… CONTINUE READING

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