Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS.

@article{Gandhi2014MetabolitePO,
  title={Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS.},
  author={Adarsh S. Gandhi and Mingshe Zhu and Shaokun Pang and Ariane Wohlfarth and Karl B. Scheidweiler and Marilyn A Huestis},
  journal={Bioanalysis},
  year={2014},
  volume={6 11},
  pages={1471-85}
}
BACKGROUND Since 2009, scheduling legislation of synthetic cannabinoids prompted new compound emergence to circumvent legal restrictions. 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone (RCS-4) is a potent cannabinoid receptor agonist sold in herbal smoking blends. Absence of parent synthetic cannabinoids in urine suggests the importance of metabolite identification for detecting RCS-4 consumption in clinical and forensic investigations. Materials & methods & Results: With 1 h human… CONTINUE READING
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