Metabolite profiling of CHO cells with different growth characteristics.

  title={Metabolite profiling of CHO cells with different growth characteristics.},
  author={Stefanie Dietmair and Mark P Hodson and Lake-Ee Quek and Nicholas E. Timmins and Panagiotis K. Chrysanthopoulos and Shana S. Jacob and Peter P. Gray and Lars K. Nielsen},
  journal={Biotechnology and bioengineering},
  volume={109 6},
Mammalian cell cultures are the predominant system for the production of recombinant proteins requiring post-translational modifications. As protein yields are a function of growth performance (among others), and performance varies greatly between culture medium (e.g., different growth rates and peak cell densities), an understanding of the biological mechanisms underpinning this variability would facilitate rational medium and process optimization, increasing product yields, and reducing costs… CONTINUE READING
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