• Corpus ID: 18448425

Metabolite patterns reveal regulatory responses to genetic perturbations

  title={Metabolite patterns reveal regulatory responses to genetic perturbations},
  author={Tolutola Oyetunde and Jeffrey J Czajka and Gang Wu and Cynthia Lo and Yinjie J. Tang},
  journal={arXiv: Molecular Networks},
Genetic and environmental perturbation experiments have been used to study microbes in a bid to gain insight into transcriptional regulation, adaptive evolution, and other cellular dynamics. These studies have potential in enabling rational strain design. Unfortunately, experimentally determined intracellular flux distribution are often inconsistent or incomparable due to different experimental conditions and methodologies. Computational strain design relies on constraint-based reconstruction… 

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