Metabolite and water apparent diffusion coefficients in the isolated rat heart: effects of ischemia.

@article{Liess2000MetaboliteAW,
  title={Metabolite and water apparent diffusion coefficients in the isolated rat heart: effects of ischemia.},
  author={Carsten Liess and George K. Radda and Kieran Clarke},
  journal={Magnetic resonance in medicine},
  year={2000},
  volume={44 2},
  pages={208-14}
}
A decrease in the apparent diffusion coefficient (ADC) of water is important in the detection of acute brain disorders, yet it is unknown whether changes in myocardial ADCs hold similar potential. Consequently, in this study a STEAM pulse sequence was modified in order to measure the ADCs of water and the (1)H-NMR detectable metabolites, taurine (an inert marker) and creatine, during perfusion, ischemia, and reperfusion in the isolated rat heart. At the short diffusion time of 50 ms, myocardial… CONTINUE READING
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