Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues

@inproceedings{Schupp2013MetaboliteAT,
  title={Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues},
  author={Michael Schupp and Fang Chen and Erika R. Briggs and Shilpa J. Rao and Helmut J. Pelzmann and Ariane R. Pessentheiner and Juliane Gertrude Bogner-Strau\ss and Mitchell A Lazar and Don A. Baldwin and Andreas Prokesch},
  booktitle={BMC Genomics},
  year={2013}
}
Fasting induces specific molecular and metabolic adaptions in most organisms. In biomedical research fasting is used in metabolic studies to synchronize nutritional states of study subjects. Because there is a lack of standardization for this procedure, we need a deeper understanding of the dynamics and the molecular mechanisms in fasting. We investigated the dynamic changes of liver gene expression and serum parameters of mice at several time points during a 48 hour fasting experiment and then… CONTINUE READING
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