Metabolism profiling of nevadensin in vitro and in vivo by UHPLC-Q-TOF-MS/MS.

  title={Metabolism profiling of nevadensin in vitro and in vivo by UHPLC-Q-TOF-MS/MS.},
  author={Caijuan Liang and Xia Zhang and Xinpeng Diao and Man Liao and Yupeng Sun and Lantong Zhang},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
Nevadensin is major constituents of Lysionotus pauciflorus Maxim. (Chinese name: Shidiaolan), which has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive. In this paper, we investigated the metabolism of nevadensin in vitro and in vivo. A strategy was firstly developed to identify the metabolites of nevadensin by using ultra-high performance liquid chromatography/quadrupole time-of-flight mass… CONTINUE READING
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