Metabolism of xenobiotics in the central nervous system: implications and challenges.

@article{Ravindranath1998MetabolismOX,
  title={Metabolism of xenobiotics in the central nervous system: implications and challenges.},
  author={Vijayalakshmi Ravindranath},
  journal={Biochemical pharmacology},
  year={1998},
  volume={56 5},
  pages={547-51}
}
The metabolism of drugs and other xenobiotics in situ in the brain has far-reaching implications in the pharmacological and pharmacodynamic effects of drugs acting on the CNS, particularly with respect to psychoactive drugs wherein a wide range of therapeutic response is typically seen in the patient population. An entirely functional cytochrome P450 (P450) monooxygenase system is known to exist in the rodent and human brain, wherein it is preferentially localized in the neuronal cells, which… CONTINUE READING

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