Metabolism of xenobiotics during percutaneous penetration: role of absorption rate and cutaneous enzyme activity.

@article{Storm1990MetabolismOX,
  title={Metabolism of xenobiotics during percutaneous penetration: role of absorption rate and cutaneous enzyme activity.},
  author={Jan E. Storm and S W Collier and Robert F Stewart and Robert L. Bronaugh},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1990},
  volume={15 1},
  pages={132-41}
}
The role of absorption rate and enzyme activity on cutaneous metabolism of topically applied xenobiotics was assessed by determining the simultaneous percutaneous penetration/metabolism of benzo[a]pyrene (B[a]P) and 7-ethoxycoumarin (7-EC) in intact, metabolically viable skin of Sencar mice, hairless guinea pigs, and humans. In addition, specific activities of aryl hydrocarbon hydroxylase (AHH) and ethoxycoumarin deethylase (ECDE) were determined in cutaneous microsomal fractions. Both… CONTINUE READING
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