Metabolism of vitamin D by human microsomal CYP2R1.

@article{Shinkyo2004MetabolismOV,
  title={Metabolism of vitamin D by human microsomal CYP2R1.},
  author={Raku Shinkyo and Toshiyuki Sakaki and Masaki Kamakura and Miho Ohta and Kuniyo Inouye},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={324 1},
  pages={451-7}
}
The activation of vitamin D requires 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney. However, it remains unclear which enzyme is relevant to vitamin D 25-hydroxylation. Recently, human CYP2R1 has been reported to be a potential candidate for a hepatic vitamin D 25-hydroxylase. Thus, vitamin D metabolism by CYP2R1 was compared with human mitochondrial CYP27A1, which used to be considered a physiologically important vitamin D(3) 25-hydroxylase. A clear difference was… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.

The Journal of steroid biochemistry and molecular biology • 2016
View 5 Excerpts
Highly Influenced

Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1.

Biochemical and biophysical research communications • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…