Metabolism of vitamin D by human microsomal CYP2R1.

  title={Metabolism of vitamin D by human microsomal CYP2R1.},
  author={Raku Shinkyo and Toshiyuki Sakaki and Masaki Kamakura and Miho Ohta and Kuniyo Inouye},
  journal={Biochemical and biophysical research communications},
  volume={324 1},
The activation of vitamin D requires 25-hydroxylation in the liver and 1alpha-hydroxylation in the kidney. However, it remains unclear which enzyme is relevant to vitamin D 25-hydroxylation. Recently, human CYP2R1 has been reported to be a potential candidate for a hepatic vitamin D 25-hydroxylase. Thus, vitamin D metabolism by CYP2R1 was compared with human mitochondrial CYP27A1, which used to be considered a physiologically important vitamin D(3) 25-hydroxylase. A clear difference was… CONTINUE READING

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