Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus

@article{Parshikov2001MetabolismOT,
  title={Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus},
  author={I A Parshikov and J. Freeman and J O Lay and J D Moody and A. J. Williams and R D Beger and J B Sutherland},
  journal={Journal of Industrial Microbiology and Biotechnology},
  year={2001},
  volume={26},
  pages={140-144}
}
To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts were analyzed by liquid chromatography. The two metabolites (26% and 15% of the A280, respectively) were identified by mass and 1H nuclear magnetic resonance spectra as N-acetylsarafloxacin and desethylene-N-acetylsarafloxacin. The biological formation of desethylene-N… CONTINUE READING

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