Metabolism of the pancreatic carcinogen N-nitroso-2,6-dimethylmorpholine by hamster liver and component cells of pancreas.

/v-Nitroso-2,6-dimethylmorpholine (NNDM) is an indirect nitrosamine carcinogen which induces ductal adenocarcinoma of the pancreas in the Syrian golden hamster. NNDM is oxidized by normal male hamster pancreas postmitochondrial supernatants (S-9) in the presence of reduced nicotinamide adenine dinucleotide phosphate and oxygen to give three major identi… (More)