Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry

  title={Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry},
  author={Xingxing Diao and Jeremy Carlier and Mingshe Zhu and Marilyn A. Huestis},
  journal={Forensic Toxicology},
PurposeThe present study aims to recommend appropriate urinary marker metabolites for documenting EG-018 consumption by investigating its metabolism in human hepatocytes.MethodsFor metabolite profiling, 10 µM EG-018 was incubated in human hepatocytes for 3 h. Metabolite identification in hepatocyte samples was accomplished with high-resolution mass spectrometry via information-dependent data acquisition.ResultsEG-018 was highly metabolized in human hepatocytes. A total of eight metabolites were… 

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