Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates.

@article{Barker1980MetabolismOT,
  title={Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates.},
  author={Steven A. Barker and John A. Monti and Samuel T. Christian},
  journal={Biochemical pharmacology},
  year={1980},
  volume={29 7},
  pages={
          1049-57
        }
}
View on PubMed
doi.org
56 Citations
Highly Influential Citations
5
Background Citations
19
Methods Citations
3

56 Citations

N, N-dimethyltryptamine: an endogenous hallucinogen.

Distribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection: application of a new solid-phase extraction LC-APcI-MS-MS-isotope dilution method.

Characterization of the synthesis of N,N-dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry.

An impurity profile of a synthetic route to the hallucinogenic N,N-dimethyltryptamine (DMT) is established and holds great promise in the area of forensic chemistry where development of reliable analytical methods for the detection, identification, and quantification of DMT are crucial and also in pharmaceutical analysis where DMT might be prepared for use in human clinical studies.

Metabolism and urinary disposition of N,N-dimethyltryptamine after oral and smoked administration: a comparative study.

Findings show that in the smoked route a shift from the highly efficient MAO-dependent to the less efficient CYP-dependent metabolism takes place, which leads to psychoactivity and is analogous to that observed in ayahuasca preparations combining DMT with MAO inhibitors.

In vivo metabolism of α,α,β,β-tetradeutero-n, N-dimethyltryptamine in rodent brain

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brain…

In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine

Specific binding of [11C]DMT to serotonin receptors in dog brain was demonstrated by a positron emission tomographic study in which 5-methoxy-N,N-dimethyltryptamine caused approximately 20% displacement of the radioligand from the receptors.

Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca.

The present results show the existence in humans of alternative metabolic routes for DMT other than biotransformation by MAO and that O-demethylation plus conjugation is an important but probably not the only metabolic route for the harmala alkaloids in humans.

Pharmacokinetics of tetrahydronorharmane (tetrahydro-β-carboline) in rats

Two different metabolic pathways are discussed, firstly, hydroxylation followed by conjugation with glucuronic and sulfuric acids and secondly, dehydrogenation, followed by oxygenation, which in female rats only traces of the conjugated metabolites are hydrolysed by arylsulfatase, whereas in male rats approximately 2/5 are cleaved by this enzyme.

Dark Classics in Chemical Neuroscience: N, N-Dimethyltryptamine (DMT).

The synthesis of DMT is covered, as well as its pharmacology, metabolism, adverse effects, and potential use in medicine.
...

References

SHOWING 1-10 OF 40 REFERENCES

Psychotomimetic drugs and brain 5-hydroxytryptamine metabolism

The in vitro identification of dimethyltryptamine (DMT) in mammalian brain and its characterization as a possible endogenous neuroregulatory agent.

Effects of iproniazid and tranylcypromine of the half-life of N,N-dimethyltryptamine in rat brain and liver.

Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine

5-Methoxytryptamine has been found in the urine of patients with rheumatic fever, and that in an order of magnitude of 30–210 µg/24 h, while N,N-dimethyl-5-hydroxytryptamine was still not demonstrated in blood.

Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. I. Tricyclic tertiary amine drugs.

  • M. Bickel
  • Chemistry, Biology
    Archives of biochemistry and biophysics
  • 1972

Behavioral effects and metabolic fate of N,N-dimethyltryptamine in mice pretreated with β-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), iproniazid and chlorpromazine

Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. II. N,N-dimethylaniline.

A review of recent studies of the biosynthesis and excretion of hallucinogens formed by methylation of neurotransmitters or related substances.

There is a striking structural similarity between several classes of compounds found in plants that produce hallucinatory or psychedelic effects in man and several neurotransmitters found in the…

On the mode of formation of tetrahydro-β-carbolines

Dose response and time course effects of N,N-dimethyltryptamine on disruption of rat shuttlebox avoidance.

DMT produced dose-dependent disruptive effects, as a sigmoid function, with 1.0 mg/kg the minimal dose causing disruption and progressively more disruption with increasing doses, reaching a plateau at the highest dose.