Metabolism of the glucuronide of N-hydroxy-2-acetylaminofluorene in the rat.


If N-G1O-AAF were involved in the mechanism of action of AAF in species susceptible to carcinogenesis by AAF, then one would also expect N-GbO-AAF to be carcinogenic. In a prelimi nary test, carried out at bow dose because of the limited availa biity of N.GbO-AAF, tumor development did not occur within 12 months after repeated subcutaneous injections of… (More)