Metabolism of the dyestuff intermediate 2,4-diaminoanisole in the rat.

@article{Grantham1979MetabolismOT,
  title={Metabolism of the dyestuff intermediate 2,4-diaminoanisole in the rat.},
  author={P. H. Grantham and T. Benjamin and L. C. Tahan and P. Roller and J. R. Miller and E. Weisburger},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1979},
  volume={9 6},
  pages={
          333-41
        }
}
1. 2,4-Diamino[ring-U-14C]anisole.2HCl administered intraperitoneally to rats is excreted chiefly via the urine (79 and 85% of the dose in 24 and 48 h, respectively). The isotope in the faeces was 2.1 and 8.9% of the dose at 24 and 48 h. 2. The major metabolic pathway was acetylation of the amine groups(s), resulting in 4-acetylamino-2-aminoanisole and 2,4-diacetylaminoanisole. 3. Oxidate pathways yielded 2,4-diacetylaminophenol (O-demethylation), 5-hydroxy-2,4-diacetylaminoanisole (ring… Expand
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