Metabolism of the antituberculosis drug ethionamide.

  title={Metabolism of the antituberculosis drug ethionamide.},
  author={Nuno Vale and Paula Gomes and H{\'e}lder A Santos},
  journal={Current drug metabolism},
  volume={14 1},
Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert their antimicrobial activity. ETH mechanism of action is thought to be… CONTINUE READING