• Biology, Medicine
  • Published in Cancer research 1994

Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme.

@article{Harris1994MetabolismOT,
  title={Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme.},
  author={James W. Harris and Arshad Rahman and B. R. Kim and F. Peter Guengerich and Jerry M. Collins},
  journal={Cancer research},
  year={1994},
  volume={54 15},
  pages={
          4026-35
        }
}
Incubation of taxol with human hepatic microsomal fractions or freshly isolated human liver slices yields three metabolite high performance liquid chromatography peaks, metabolite A, metabolite B, and 6 alpha-hydroxytaxol. These metabolites are formed in patients given taxol, with 6 alpha-hydroxytaxol formation representing the principal biotransformation pathway. Metabolite B and 6 alpha-hydroxytaxol are shown to be products of different, highly regioselective cytochrome P-450 (P450) enzymes… CONTINUE READING

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References

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Hepatic metabolism and biliary excretion of Taxol in rats and humans.

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients.