Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry

@article{Wohlfarth2014MetabolismOS,
  title={Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry},
  author={Ariane Wohlfarth and Adarsh Gandhi and Shaokun Pang and Mingshe Zhu and Karl B. Scheidweiler and Marilyn A. Huestis},
  journal={Analytical and Bioanalytical Chemistry},
  year={2014},
  volume={406},
  pages={1763-1780}
}
AbstractBackgroundPB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are new synthetic cannabinoids with a quinoline substructure and the first marketed substances with an ester bond linkage. No human metabolism data are currently available, making it difficult to document PB-22 and 5F-PB-22 intake from urine analysis, and complicating assessment of the drugs’ pharmacodynamic and toxicological… 
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Differentiation and identification of 5F-PB-22 and its isomers.
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