Metabolism of styrene oxide to styrene glycol by mouse liver and lung.

@article{Carlson1998MetabolismOS,
  title={Metabolism of styrene oxide to styrene glycol by mouse liver and lung.},
  author={Gary P. Carlson},
  journal={Journal of toxicology and environmental health. Part A},
  year={1998},
  volume={53 1},
  pages={19-27}
}
  • Gary P. Carlson
  • Published 1998 in
    Journal of toxicology and environmental health…
Styrene is a widely used chemical that causes both liver and lung damage in mice. Strain and sex differences in susceptibility to styrene-induced toxicity have been reported. Understanding the relationship of the metabolism of styrene to its toxicity depends upon knowing the balance between the bioactivation of styrene to the epoxide by cytochromes P-450 and the detoxication of the oxide to the glycol by microsomal epoxide hydrolase. When hepatic and pulmonary microsomal preparations from non… CONTINUE READING

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