[Metabolism of skeletal muscle proteins in experimental hypokinesia in rats].


Using a radioindicator method, the metabolism of sarcoplasmic and myofibrillar proteins was studied in vivo at different stages of hypokinesia in rats. It was shown that the true muscle atrophy and the lowered content of both protein fractions during the first two weeks are due to sharp inhibition of sarcoplasmic protein biosynthesis as well as to deceleration of biosynthesis and acceleration of degradation of actomyosin. In hypokinesia the muscle mass does not increase within 3-8 weeks largely due to the acceleration of degradation of the de novo synthesized components of contractile proteins. In early hypokinesia a stressory mechanism plays an essential role in the pathogenesis of protein metabolism disturbances.

Cite this paper

@article{Kazarian1985MetabolismOS, title={[Metabolism of skeletal muscle proteins in experimental hypokinesia in rats].}, author={V A Kazarian and G D Shitov and E. A. Rapoport}, journal={Biokhimii︠a︡}, year={1985}, volume={50 8}, pages={1305-11} }